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Kwon, Y

Mechanisms that commonly induce ROS generation in viral infections include the deregulation of mitochondrial function, activation and upregulation of NOX production, and modification of the Nrf2/ARE pathway, with superoxide being the most commonly produced ROS 55

These epigenetic changes were associated with excessive visceral fat accumulation and disorders of the metabolic syndrome including insulin resistance/hyperinsulinemia, high circulating homocysteine, endotoxemia, elevated leptin concentrations, lower adiponectin and a higher risk of diabetes [172]

Diphenhydramine is positioned as a defined rescue step for acute symptom spikes